| November 13, 2027 | SOUTH CAROLINA STATE BULLDOGS | L 97-99 | 0-1 | O. Yearwood 21 | T. Kickert 7 | J. Russell 6 |
| November 16, 2027 | @ Penn State Nittany Lions | L 69-71 | 0-2 | E. Flint 13 | M. Crenshaw 6 | E. Flint 9 |
| November 18, 2027 | @ Sam Houston State Bearkats | L 74-84 | 0-3 | M. Crenshaw 16 | J. Russell 6 | M. Stoudamire 8 |
| November 22, 2027 | CENTRAL MICHIGAN CHIPPEWAS | W 98-86 | 1-3 | R. Moore 22 | M. Crenshaw 6 | O. Yearwood 6 |
| November 26, 2027 | OMAHA MAVERICKS | W 80-69 | 2-3 | J. Russell 20 | M. Crenshaw 7 | E. Flint 10 |
| November 29, 2027 | @ Oklahoma Sooners | L 73-107 | 2-4 | M. Stoudamire 14 | M. Crenshaw 4 | M. Stoudamire 9 |
| December 5, 2027 | @ Texas-El Paso Miners | L 63-73 | 2-5 | J. Russell 11 | T. Kickert 5 | O. Yearwood 6 |
| December 8, 2027 | @ #5 Gonzaga Bulldogs | L 61-84 | 2-6 | O. Yearwood 13 | M. Crenshaw 4 | R. Moore 9 |
| December 13, 2027 | @ Eastern Michigan Eagles | L 78-85 | 2-7 | M. Stoudamire 15 | R. Moore 5 | R. Moore 5 |
| December 19, 2027 | @ Morgan State Bears | L 76-101 | 2-8 | T. Kickert 14 | M. Crenshaw 5 | M. Stoudamire 7 |
| December 26, 2027 | @ Belmont Bruins* | L 70-84 | 2-9 | J. Russell 16 | M. Crenshaw 4 | M. Stoudamire 8 |
| December 28, 2027 | MURRAY STATE RACERS* | W 95-77 | 3-9 | O. Yearwood 23 | M. Crenshaw 7 | O. Yearwood 7 |
| January 2, 2028 | @ Valparaiso Beacons* | L 64-91 | 3-10 | T. Kickert 10 | M. Crenshaw 2 | R. Moore 9 |
| January 4, 2028 | NORTHERN IOWA PANTHERS* | L 73-83 | 3-11 | J. Russell 21 | M. Crenshaw 4 | O. Yearwood 8 |
| January 11, 2028 | ILLINOIS STATE REDBIRDS* | L 53-81 | 3-12 | E. Flint 9 | E. Flint 2 | O. Yearwood 5 |
| January 13, 2028 | @ Illinois-Chicago Flames* | L 69-82 | 3-13 | M. Crenshaw 13 | M. Crenshaw 4 | M. Stoudamire 7 |
| January 20, 2028 | BRADLEY BRAVES* | L 58-75 | 3-14 | M. Stoudamire 14 | M. Crenshaw 6 | E. Flint 6 |
| January 23, 2028 | INDIANA STATE SYCAMORES* | L 81-83 | 3-15 | J. Russell 19 | M. Crenshaw 8 | M. Crenshaw 5 |
| January 27, 2028 | @ Southern Illinois Salukis* | L 106-111 OT | 3-16 | T. Kickert 16 | M. Crenshaw 7 | R. Moore 6 |
| January 30, 2028 | @ Drake Bulldogs* | L 75-82 | 3-17 | T. Kickert 17 | M. Crenshaw 4 | E. Flint 5 |
| February 1, 2028 | @ Northern Iowa Panthers* | L 67-80 | 3-18 | R. Moore 12 | M. Crenshaw 3 | J. Russell 6 |
| February 3, 2028 | ILLINOIS-CHICAGO FLAMES* | L 74-77 | 3-19 | R. Moore 14 | M. Crenshaw 8 | O. Yearwood 9 |
| February 8, 2028 | @ Illinois State Redbirds* | L 75-95 | 3-20 | M. Crenshaw 18 | M. Crenshaw 4 | M. Stoudamire 9 |
| February 13, 2028 | @ Murray State Racers* | L 56-73 | 3-21 | J. Russell 14 | M. Crenshaw 4 | R. Moore 6 |
| February 15, 2028 | SOUTHERN ILLINOIS SALUKIS* | L 66-78 | 3-22 | J. Russell 12 | M. Crenshaw 3 | M. Stoudamire 10 |
| February 17, 2028 | DRAKE BULLDOGS* | W 97-79 | 4-22 | M. Crenshaw 17 | M. Crenshaw 5 | O. Yearwood 8 |
| February 22, 2028 | @ Bradley Braves* | L 62-76 | 4-23 | E. Hines 14 | M. Crenshaw 4 | O. Yearwood 10 |
| February 24, 2028 | @ Indiana State Sycamores* | W 83-80 | 5-23 | M. Crenshaw 20 | J. Russell 4 | M. Stoudamire 9 |
| March 1, 2028 | BELMONT BRUINS* | L 64-97 | 5-24 | E. Flint 12 | T. Kickert 4 | O. Yearwood 6 |
| March 3, 2028 | VALPARAISO BEACONS* | L 73-91 | 5-25 | J. Russell 13 | M. Crenshaw 4 | E. Flint 5 |
| March 6, 2028 | @ Indiana State Sycamores (13-16, 9-3 Home) MVC Tournament | - | | | | |
