| November 15, 2027 | @ Florida State Seminoles | W 89-73 | 1-0 | S. Pryor 21 | A. Cox 8 | C. Bailey 7 |
| November 18, 2027 | BOSTON UNIVERSITY TERRIERS | W 87-79 | 2-0 | S. Pryor 23 | S. Pryor 6 | A. Cox 10 |
| November 22, 2027 | TOLEDO ROCKETS | W 78-60 | 3-0 | A. Cox 18 | S. Pryor 6 | G. Thorne 8 |
| November 25, 2027 | @ Southern Methodist Mustangs | L 69-71 | 3-1 | S. Pryor 18 | A. Cox 4 | A. Cox 7 |
| November 29, 2027 | @ #5 North Carolina Tar Heels | L 60-76 | 3-2 | C. Bailey 21 | B. McCall 3 | B. McCall 7 |
| December 2, 2027 | MARSHALL THUNDERING HERD | W 96-83 | 4-2 | G. Thorne 19 | G. Thorne 3 | G. Thorne 8 |
| December 6, 2027 | INDIANA STATE SYCAMORES | W 86-61 | 5-2 | J. Young 19 | S. Pryor 10 | A. Cox 6 |
| December 13, 2027 | MANHATTAN JASPERS | W 76-71 | 6-2 | J. Young 16 | A. Cox 6 | B. McCall 6 |
| December 20, 2027 | ARMY BLACK KNIGHTS | W 97-67 | 7-2 | J. Young 22 | S. Pryor 6 | B. McCall 12 |
| December 26, 2027 | @ St. Johns Red Storm* | L 84-96 | 7-3 | C. Bailey 22 | A. Cox 6 | C. Bailey 7 |
| December 30, 2027 | BUTLER BULLDOGS* | L 77-81 | 7-4 | C. Bailey 21 | A. Cox 4 | B. McCall 8 |
| January 2, 2028 | @ #20 Villanova Wildcats* | W 89-78 | 8-4 | G. Thorne 20 | S. Pryor 5 | C. Bailey 7 |
| January 4, 2028 | @ Georgetown Hoyas* | L 74-81 | 8-5 | C. Bailey 22 | J. Young 5 | C. Bailey 13 |
| January 6, 2028 | #2 MARQUETTE GOLDEN EAGLES* | L 80-87 | 8-6 | J. Young 12 | A. Cox 6 | B. McCall 9 |
| January 11, 2028 | @ Xavier Musketeers* | L 66-77 | 8-7 | G. Thorne 15 | A. Cox 6 | G. Thorne 13 |
| January 13, 2028 | @ Connecticut Huskies* | L 81-89 OT | 8-8 | S. Pryor 16 | J. Young 7 | G. Thorne 13 |
| January 20, 2028 | #18 CREIGHTON BLUE JAYS* | W 76-63 | 9-8 | G. Thorne 17 | G. Thorne 6 | B. McCall 10 |
| January 23, 2028 | GEORGETOWN HOYAS* | W 78-71 | 10-8 | G. Thorne 16 | S. Pryor 9 | G. Thorne 11 |
| January 27, 2028 | PROVIDENCE FRIARS* | W 73-63 | 11-8 | S. Pryor 16 | J. Young 4 | G. Thorne 7 |
| January 30, 2028 | SETON HALL PIRATES* | W 77-75 | 12-8 | J. Young 23 | S. Pryor 7 | A. Cox 7 |
| February 1, 2028 | @ #1 Marquette Golden Eagles* | L 63-76 | 12-9 | A. Cox 17 | A. Cox 2 | G. Thorne 7 |
| February 3, 2028 | @ Butler Bulldogs* | L 60-67 | 12-10 | J. Young 10 | S. Pryor 3 | A. Cox 8 |
| February 8, 2028 | CONNECTICUT HUSKIES* | W 78-65 | 13-10 | J. Young 24 | S. Pryor 5 | B. McCall 12 |
| February 10, 2028 | XAVIER MUSKETEERS* | W 92-90 OT | 14-10 | G. Thorne 24 | J. Young 4 | G. Thorne 11 |
| February 15, 2028 | @ Providence Friars* | L 93-99 OT | 14-11 | J. Young 22 | A. Cox 6 | G. Thorne 9 |
| February 17, 2028 | @ Seton Hall Pirates* | L 54-75 | 14-12 | B. McCall 11 | J. Young 3 | B. McCall 7 |
| February 22, 2028 | VILLANOVA WILDCATS* | W 83-69 | 15-12 | A. Cox 18 | A. Cox 6 | G. Thorne 8 |
| February 24, 2028 | ST. JOHNS RED STORM* | W 83-67 | 16-12 | G. Thorne 21 | S. Pryor 6 | G. Thorne 12 |
| March 1, 2028 | @ Creighton Blue Jays* | L 63-83 | 16-13 | G. Thorne 21 | A. Cox 6 | B. McCall 8 |
| March 9, 2028 | CREIGHTON BLUE JAYS Big East Tournament | L 77-88 | 16-14 | C. Bailey 20 | S. Pryor 3 | C. Bailey 11 |
