| November 15, 2027 | @ Florida State Seminoles | W 89-73 | 1-0 | S. Pryor 21 | A. Cox 8 | C. Bailey 7 |
| November 18, 2027 | BOSTON UNIVERSITY TERRIERS | W 87-79 | 2-0 | S. Pryor 23 | S. Pryor 6 | A. Cox 10 |
| November 22, 2027 | TOLEDO ROCKETS | W 78-60 | 3-0 | A. Cox 18 | S. Pryor 6 | G. Thorne 8 |
| November 25, 2027 | @ Southern Methodist Mustangs | L 69-71 | 3-1 | S. Pryor 18 | A. Cox 4 | A. Cox 7 |
| November 29, 2027 | @ #5 North Carolina Tar Heels | L 60-76 | 3-2 | C. Bailey 21 | B. McCall 3 | B. McCall 7 |
| December 2, 2027 | MARSHALL THUNDERING HERD | W 96-83 | 4-2 | G. Thorne 19 | G. Thorne 3 | G. Thorne 8 |
| December 6, 2027 | INDIANA STATE SYCAMORES | W 86-61 | 5-2 | J. Young 19 | S. Pryor 10 | A. Cox 6 |
| December 13, 2027 | MANHATTAN JASPERS | W 76-71 | 6-2 | J. Young 16 | A. Cox 6 | B. McCall 6 |
| December 20, 2027 | ARMY BLACK KNIGHTS (3-6, 0-6 Away) | - | | | | |
| December 26, 2027 | @ St. Johns Red Storm (4-4, 0-0, 3-2 Home)* | - | | | | |
| December 30, 2027 | BUTLER BULLDOGS (6-4, 0-0, 1-3 Away)* | - | | | | |
| January 2, 2028 | @ Villanova Wildcats (7-0, 0-0, 4-0 Home)* | - | | | | |
| January 4, 2028 | @ Georgetown Hoyas (8-0, 0-0, 7-0 Home)* | - | | | | |
| January 6, 2028 | MARQUETTE GOLDEN EAGLES (10-1, 0-0, 1-0 Away)* | - | | | | |
| January 11, 2028 | @ Xavier Musketeers (5-4, 0-0, 2-2 Home)* | - | | | | |
| January 13, 2028 | @ Connecticut Huskies (2-6, 0-0, 1-4 Home)* | - | | | | |
| January 20, 2028 | CREIGHTON BLUE JAYS (8-2, 0-0, 0-0 Away)* | - | | | | |
| January 23, 2028 | GEORGETOWN HOYAS (8-0, 0-0, 1-0 Away)* | - | | | | |
| January 27, 2028 | PROVIDENCE FRIARS (7-3, 0-0, 1-0 Away)* | - | | | | |
| January 30, 2028 | SETON HALL PIRATES (9-1, 0-0, 1-0 Away)* | - | | | | |
| February 1, 2028 | @ Marquette Golden Eagles (10-1, 0-0, 5-1 Home)* | - | | | | |
| February 3, 2028 | @ Butler Bulldogs (6-4, 0-0, 2-1 Home)* | - | | | | |
| February 8, 2028 | CONNECTICUT HUSKIES (2-6, 0-0, 0-1 Away)* | - | | | | |
| February 10, 2028 | XAVIER MUSKETEERS (5-4, 0-0, 2-1 Away)* | - | | | | |
| February 15, 2028 | @ Providence Friars (7-3, 0-0, 3-3 Home)* | - | | | | |
| February 17, 2028 | @ Seton Hall Pirates (9-1, 0-0, 5-1 Home)* | - | | | | |
| February 22, 2028 | VILLANOVA WILDCATS (7-0, 0-0, 3-0 Away)* | - | | | | |
| February 24, 2028 | ST. JOHNS RED STORM (4-4, 0-0, 1-1 Away)* | - | | | | |
| March 1, 2028 | @ Creighton Blue Jays (8-2, 0-0, 6-1 Home)* | - | | | | |
