| November 15, 2027 | NORTHWESTERN STATE DEMONS | W 73-52 | 1-0 | R. Kallenberger 20 | E. Johnson 6 | D. Buturovic 13 |
| November 18, 2027 | PENNSYLVANIA QUAKERS | W 81-73 | 2-0 | D. Buturovic 32 | R. Kallenberger 5 | T. Weaver 13 |
| November 22, 2027 | #17 LOUISVILLE CARDINALS | L 86-97 | 2-1 | M. Guiden 29 | R. Kallenberger 7 | D. Buturovic 7 |
| November 25, 2027 | MONMOUTH HAWKS ESPN Events Invitational | W 82-60 | 3-1 | R. Kallenberger 14 | R. Kallenberger 5 | T. Weaver 11 |
| November 26, 2027 | TOLEDO ROCKETS ESPN Events Invitational | W 78-74 | 4-1 | D. Buturovic 20 | M. Guiden 7 | T. Weaver 13 |
| November 27, 2027 | @ #6 West Virginia Mountaineers ESPN Events Invitational | L 77-80 OT | 4-2 | M. Guiden 30 | R. Kallenberger 9 | T. Weaver 14 |
| November 29, 2027 | TENNESSEE-MARTIN SKYHAWKS | W 83-76 | 5-2 | R. Kallenberger 29 | T. Weaver 4 | M. Guiden 8 |
| December 2, 2027 | BOWLING GREEN STATE FALCONS | W 67-62 | 6-2 | M. Guiden 19 | R. Kallenberger 3 | T. Weaver 11 |
| December 6, 2027 | SAN JOSE STATE SPARTANS | W 80-52 | 7-2 | M. Guiden 22 | R. Kallenberger 4 | T. Weaver 9 |
| December 13, 2027 | WYOMING COWBOYS | W 77-60 | 8-2 | M. Guiden 31 | R. Kallenberger 9 | T. Weaver 10 |
| December 20, 2027 | RICE OWLS | W 89-66 | 9-2 | D. Buturovic 20 | R. Kallenberger 7 | T. Weaver 15 |
| December 26, 2027 | XAVIER MUSKETEERS* | W 78-65 | 10-2 | R. Kallenberger 18 | E. Johnson 6 | T. Weaver 14 |
| December 28, 2027 | @ Providence Friars* | L 47-49 | 10-3 | D. Buturovic 13 | R. Kallenberger 4 | T. Weaver 11 |
| December 30, 2027 | @ Seton Hall Pirates* | L 76-84 | 10-4 | D. Buturovic 19 | R. Kallenberger 5 | T. Weaver 8 |
| January 2, 2028 | CONNECTICUT HUSKIES* | W 70-61 | 11-4 | M. Guiden 23 | M. Guiden 4 | D. Buturovic 11 |
| January 6, 2028 | @ St. Johns Red Storm* | L 56-59 | 11-5 | M. Guiden 14 | M. Guiden 6 | O. Zimmer 10 |
| January 9, 2028 | @ #19 Villanova Wildcats* | W 86-79 | 12-5 | D. Buturovic 18 | M. Guiden 10 | T. Weaver 9 |
| January 13, 2028 | #1 MARQUETTE GOLDEN EAGLES* | W 77-66 | 13-5 | R. Kallenberger 15 | M. Guiden 5 | E. Johnson 10 |
| January 16, 2028 | #24 BUTLER BULLDOGS* | L 67-82 | 13-6 | M. Guiden 21 | E. Johnson 5 | E. Johnson 6 |
| January 18, 2028 | @ Georgetown Hoyas* | L 75-80 | 13-7 | M. Guiden 25 | M. Guiden 5 | T. Weaver 9 |
| January 20, 2028 | @ DePaul Blue Demons* | L 63-76 | 13-8 | R. Kallenberger 14 | M. Guiden 7 | T. Weaver 12 |
| January 25, 2028 | #19 VILLANOVA WILDCATS* | W 80-60 | 14-8 | R. Kallenberger 24 | M. Guiden 5 | T. Weaver 19 |
| February 3, 2028 | @ Xavier Musketeers* | L 66-79 | 14-9 | R. Kallenberger 10 | M. Guiden 4 | D. Buturovic 10 |
| February 6, 2028 | @ Connecticut Huskies* | L 70-76 | 14-10 | M. Guiden 23 | R. Kallenberger 4 | T. Weaver 9 |
| February 10, 2028 | SETON HALL PIRATES* | L 73-81 | 14-11 | M. Guiden 20 | R. Kallenberger 6 | O. Zimmer 10 |
| February 13, 2028 | PROVIDENCE FRIARS* | L 70-90 | 14-12 | E. Johnson 12 | M. Guiden 4 | T. Weaver 5 |
| February 15, 2028 | ST. JOHNS RED STORM* | L 67-69 | 14-13 | M. Guiden 18 | R. Kallenberger 4 | T. Weaver 12 |
| February 22, 2028 | @ #1 Marquette Golden Eagles* | L 78-105 | 14-14 | R. Kallenberger 17 | M. Guiden 5 | T. Weaver 6 |
| February 24, 2028 | @ #22 Butler Bulldogs* | L 76-79 | 14-15 | M. Guiden 20 | M. Guiden 5 | D. Buturovic 9 |
| March 1, 2028 | DEPAUL BLUE DEMONS* | W 83-63 | 15-15 | M. Guiden 26 | M. Guiden 7 | T. Weaver 8 |
| March 3, 2028 | GEORGETOWN HOYAS* | W 82-58 | 16-15 | D. Buturovic 18 | R. Kallenberger 7 | T. Weaver 8 |
| March 9, 2028 | @ DePaul Blue Demons Big East Tournament | W 88-77 | 17-15 | R. Kallenberger 16 | E. Johnson 5 | O. Zimmer 9 |
| March 10, 2028 | @ Providence Friars Big East Tournament | L 64-72 | 17-16 | M. Guiden 18 | R. Kallenberger 6 | M. Guiden 8 |
