| November 15, 2027 | NORTHWESTERN STATE DEMONS | W 73-52 | 1-0 | R. Kallenberger 20 | E. Johnson 6 | D. Buturovic 13 |
| November 18, 2027 | PENNSYLVANIA QUAKERS | W 81-73 | 2-0 | D. Buturovic 32 | R. Kallenberger 5 | T. Weaver 13 |
| November 22, 2027 | #17 LOUISVILLE CARDINALS | L 86-97 | 2-1 | M. Guiden 29 | R. Kallenberger 7 | D. Buturovic 7 |
| November 25, 2027 | MONMOUTH HAWKS ESPN Events Invitational | W 82-60 | 3-1 | R. Kallenberger 14 | R. Kallenberger 5 | T. Weaver 11 |
| November 26, 2027 | TOLEDO ROCKETS ESPN Events Invitational | W 78-74 | 4-1 | D. Buturovic 20 | M. Guiden 7 | T. Weaver 13 |
| November 27, 2027 | @ #6 West Virginia Mountaineers ESPN Events Invitational | L 77-80 OT | 4-2 | M. Guiden 30 | R. Kallenberger 9 | T. Weaver 14 |
| November 29, 2027 | TENNESSEE-MARTIN SKYHAWKS | W 83-76 | 5-2 | R. Kallenberger 29 | T. Weaver 4 | M. Guiden 8 |
| December 2, 2027 | BOWLING GREEN STATE FALCONS | W 67-62 | 6-2 | M. Guiden 19 | R. Kallenberger 3 | T. Weaver 11 |
| December 6, 2027 | SAN JOSE STATE SPARTANS | W 80-52 | 7-2 | M. Guiden 22 | R. Kallenberger 4 | T. Weaver 9 |
| December 13, 2027 | WYOMING COWBOYS | W 77-60 | 8-2 | M. Guiden 31 | R. Kallenberger 9 | T. Weaver 10 |
| December 20, 2027 | RICE OWLS (2-6, 0-3 Away) | - | | | | |
| December 26, 2027 | XAVIER MUSKETEERS (5-4, 0-0, 2-1 Away)* | - | | | | |
| December 28, 2027 | @ Providence Friars (7-3, 0-0, 3-3 Home)* | - | | | | |
| December 30, 2027 | @ Seton Hall Pirates (9-1, 0-0, 5-1 Home)* | - | | | | |
| January 2, 2028 | CONNECTICUT HUSKIES (2-6, 0-0, 0-1 Away)* | - | | | | |
| January 6, 2028 | @ St. Johns Red Storm (4-4, 0-0, 3-2 Home)* | - | | | | |
| January 9, 2028 | @ Villanova Wildcats (7-0, 0-0, 4-0 Home)* | - | | | | |
| January 13, 2028 | MARQUETTE GOLDEN EAGLES (10-1, 0-0, 1-0 Away)* | - | | | | |
| January 16, 2028 | BUTLER BULLDOGS (6-4, 0-0, 1-3 Away)* | - | | | | |
| January 18, 2028 | @ Georgetown Hoyas (8-0, 0-0, 7-0 Home)* | - | | | | |
| January 20, 2028 | @ DePaul Blue Demons (6-2, 0-0, 5-0 Home)* | - | | | | |
| January 25, 2028 | VILLANOVA WILDCATS (7-0, 0-0, 3-0 Away)* | - | | | | |
| February 3, 2028 | @ Xavier Musketeers (5-4, 0-0, 2-2 Home)* | - | | | | |
| February 6, 2028 | @ Connecticut Huskies (2-6, 0-0, 1-4 Home)* | - | | | | |
| February 10, 2028 | SETON HALL PIRATES (9-1, 0-0, 1-0 Away)* | - | | | | |
| February 13, 2028 | PROVIDENCE FRIARS (7-3, 0-0, 1-0 Away)* | - | | | | |
| February 15, 2028 | ST. JOHNS RED STORM (4-4, 0-0, 1-1 Away)* | - | | | | |
| February 22, 2028 | @ Marquette Golden Eagles (10-1, 0-0, 5-1 Home)* | - | | | | |
| February 24, 2028 | @ Butler Bulldogs (6-4, 0-0, 2-1 Home)* | - | | | | |
| March 1, 2028 | DEPAUL BLUE DEMONS (6-2, 0-0, 1-2 Away)* | - | | | | |
| March 3, 2028 | GEORGETOWN HOYAS (8-0, 0-0, 1-0 Away)* | - | | | | |
