| November 18, 2027 | #9 FLORIDA GATORS | W 107-92 | 1-0 | J. Clay 19 | J. Clay 7 | R. Oates 9 |
| November 21, 2027 | ILLINOIS STATE REDBIRDS WSSN Classic | W 84-54 | 2-0 | J. Clay 15 | J. Clay 5 | G. Watkins 9 |
| November 22, 2027 | STANFORD CARDINAL WSSN Classic | W 96-73 | 3-0 | C. Cherry 24 | G. Watkins 5 | K. Weathers 12 |
| November 23, 2027 | @ #22 Purdue Boilermakers WSSN Classic | W 86-74 | 4-0 | R. Oates 27 | J. Clay 5 | R. Oates 12 |
| November 25, 2027 | PURDUE-FORT WAYNE MASTODONS | W 92-71 | 5-0 | K. Weathers 20 | B. Spitler 6 | G. Watkins 7 |
| November 29, 2027 | #12 KENTUCKY WILDCATS | W 94-70 | 6-0 | R. Oates 25 | J. Clay 9 | K. Weathers 11 |
| December 1, 2027 | @ #24 Arizona Wildcats | L 89-97 | 6-1 | R. Oates 23 | B. Spitler 6 | R. Oates 13 |
| December 8, 2027 | @ #19 Saint Marys Gaels | L 73-94 | 6-2 | R. Oates 16 | J. Clay 4 | R. Oates 14 |
| December 15, 2027 | #5 GONZAGA BULLDOGS | W 74-58 | 7-2 | R. Oates 22 | B. Spitler 11 | G. Watkins 10 |
| December 21, 2027 | FLORIDA ATLANTIC OWLS | W 75-59 | 8-2 | R. Oates 23 | G. Watkins 7 | R. Oates 12 |
| December 24, 2027 | MIAMI (OH) REDHAWKS | W 93-77 | 9-2 | B. Spitler 22 | B. Spitler 2 | R. Oates 8 |
| December 28, 2027 | VILLANOVA WILDCATS* | W 86-68 | 10-2 | R. Oates 21 | G. Watkins 4 | G. Watkins 11 |
| December 30, 2027 | GEORGETOWN HOYAS* | W 100-75 | 11-2 | R. Oates 34 | G. Watkins 9 | R. Oates 15 |
| January 2, 2028 | @ Providence Friars* | W 79-70 | 12-2 | J. Clay 17 | B. Spitler 5 | R. Oates 12 |
| January 4, 2028 | @ #16 Creighton Blue Jays* | L 82-98 | 12-3 | B. Spitler 18 | J. Clay 5 | R. Oates 12 |
| January 11, 2028 | ST. JOHNS RED STORM* | W 91-74 | 13-3 | J. Clay 19 | R. Oates 4 | K. Weathers 12 |
| January 13, 2028 | MARQUETTE GOLDEN EAGLES* | W 71-54 | 14-3 | R. Oates 22 | B. Spitler 6 | R. Oates 8 |
| January 20, 2028 | @ Butler Bulldogs* | W 89-65 | 15-3 | R. Oates 27 | J. Clay 6 | G. Watkins 13 |
| January 23, 2028 | @ Xavier Musketeers* | W 82-72 | 16-3 | K. Weathers 20 | J. Clay 11 | R. Oates 15 |
| January 25, 2028 | SETON HALL PIRATES* | W 74-61 | 17-3 | J. Clay 23 | B. Spitler 5 | R. Oates 11 |
| January 27, 2028 | #13 CREIGHTON BLUE JAYS* | W 103-87 | 18-3 | R. Oates 37 | B. Spitler 8 | R. Oates 14 |
| February 1, 2028 | @ DePaul Blue Demons* | W 89-62 | 19-3 | R. Oates 22 | G. Watkins 8 | R. Oates 13 |
| February 6, 2028 | PROVIDENCE FRIARS* | W 107-75 | 20-3 | R. Oates 27 | G. Watkins 7 | G. Watkins 14 |
| February 8, 2028 | @ #23 Marquette Golden Eagles* | L 81-94 | 20-4 | J. Clay 21 | B. Spitler 9 | K. Weathers 7 |
| February 10, 2028 | @ St. Johns Red Storm* | W 95-69 | 21-4 | R. Oates 18 | B. Spitler 8 | G. Watkins 11 |
| February 15, 2028 | DEPAUL BLUE DEMONS* | W 92-69 | 22-4 | R. Oates 32 | B. Spitler 6 | R. Oates 12 |
| February 17, 2028 | @ Seton Hall Pirates* | L 82-83 | 22-5 | B. Spitler 17 | B. Spitler 4 | G. Watkins 7 |
| February 22, 2028 | BUTLER BULLDOGS* | W 79-60 | 23-5 | R. Oates 23 | G. Watkins 4 | R. Oates 12 |
| February 24, 2028 | XAVIER MUSKETEERS* | W 92-75 | 24-5 | K. Weathers 20 | B. Spitler 7 | K. Weathers 10 |
| March 1, 2028 | @ Georgetown Hoyas* | W 105-86 | 25-5 | J. Clay 26 | J. Clay 6 | R. Oates 11 |
| March 3, 2028 | @ Villanova Wildcats* | W 89-63 | 26-5 | R. Oates 29 | B. Spitler 4 | R. Oates 12 |
| March 10, 2028 | TBD Big East Tournament | - | | | | |
