| November 13, 2027 | ST. THOMAS TOMMIES | W 63-58 | 1-0 | L. Fletcher 15 | J. Curry 3 | E. Xavier 9 |
| November 15, 2027 | TOLEDO ROCKETS | L 90-96 OT | 1-1 | C. Cole 18 | J. Curry 3 | E. Xavier 10 |
| November 18, 2027 | LOYOLA MARYMOUNT LIONS | W 65-43 | 2-1 | L. Fletcher 12 | J. Curry 5 | E. Xavier 13 |
| November 22, 2027 | MOREHEAD STATE EAGLES | W 85-64 | 3-1 | J. Curry 17 | L. Fletcher 4 | B. Hedrick 9 |
| November 25, 2027 | PRINCETON TIGERS | W 81-60 | 4-1 | L. Fletcher 14 | J. Curry 5 | B. Hedrick 6 |
| November 29, 2027 | TENNESSEE STATE TIGERS | W 81-70 | 5-1 | C. Cole 17 | J. Curry 5 | D. McFall 8 |
| December 2, 2027 | MISSISSIPPI VALLEY DELTA DEVILS | W 80-68 | 6-1 | J. Curry 17 | J. Curry 4 | L. Fletcher 7 |
| December 6, 2027 | MORGAN STATE BEARS | W 68-66 | 7-1 | J. Curry 13 | J. Curry 4 | E. Xavier 14 |
| December 13, 2027 | STONY BROOK SEAWOLVES | L 70-78 | 7-2 | J. Curry 14 | E. Xavier 3 | C. Cole 7 |
| December 20, 2027 | GEORGETOWN HOYAS | L 66-73 | 7-3 | C. Cole 12 | J. Curry 4 | D. McFall 7 |
| December 26, 2027 | BOSTON COLLEGE EAGLES (6-4, 0-0, 0-2 Away)* | - | | | | |
| December 28, 2027 | @ Virginia Tech Hokies (5-4, 0-0, 5-3 Home)* | - | | | | |
| January 2, 2028 | @ Florida State Seminoles (8-3, 0-0, 6-2 Home)* | - | | | | |
| January 4, 2028 | CALIFORNIA GOLDEN BEARS (6-3, 0-0, 1-0 Away)* | - | | | | |
| January 9, 2028 | NOTRE DAME FIGHTING IRISH (5-5, 0-0, 0-1 Away)* | - | | | | |
| January 11, 2028 | SOUTHERN METHODIST MUSTANGS (5-5, 0-0, 0-1 Away)* | - | | | | |
| January 16, 2028 | WAKE FOREST DEMON DEACONS (6-3, 0-0, 0-1 Away)* | - | | | | |
| January 18, 2028 | @ Syracuse Orange (3-6, 0-0, 3-5 Home)* | - | | | | |
| January 23, 2028 | DUKE BLUE DEVILS (7-4, 0-0, 0-2 Away)* | - | | | | |
| January 25, 2028 | @ NC-State Wolfpack (5-4, 0-0, 5-3 Home)* | - | | | | |
| January 30, 2028 | NORTH CAROLINA TAR HEELS (9-2, 0-0, 0-0 Away)* | - | | | | |
| February 1, 2028 | @ Stanford Cardinal (8-2, 0-0, 6-1 Home)* | - | | | | |
| February 6, 2028 | LOUISVILLE CARDINALS (9-2, 0-0, 1-0 Away)* | - | | | | |
| February 8, 2028 | @ Georgia Tech Yellow Jackets (9-2, 0-0, 5-0 Home)* | - | | | | |
| February 13, 2028 | @ Pittsburgh Panthers (10-2, 0-0, 7-0 Home)* | - | | | | |
| February 15, 2028 | @ Miami (FL) Hurricanes (6-3, 0-0, 6-0 Home)* | - | | | | |
| February 20, 2028 | @ Virginia Cavaliers (10-1, 0-0, 5-0 Home)* | - | | | | |
| February 22, 2028 | GEORGIA TECH YELLOW JACKETS (9-2, 0-0, 1-2 Away)* | - | | | | |
| February 27, 2028 | @ California Golden Bears (6-3, 0-0, 5-2 Home)* | - | | | | |
| March 1, 2028 | STANFORD CARDINAL (8-2, 0-0, 0-1 Away)* | - | | | | |
