| November 16, 2027 | NC-CENTRAL EAGLES | W 72-54 | 1-0 | D. Lampley 16 | I. Haskins 4 | D. Lampley 7 |
| November 19, 2027 | RIDER BRONCS | W 82-46 | 2-0 | D. Donovan 21 | I. Haskins 6 | D. Lampley 10 |
| November 23, 2027 | @ #1 Kansas Jayhawks | L 54-67 | 2-1 | D. Donovan 10 | I. Haskins 6 | I. Haskins 7 |
| November 26, 2027 | APPALACHIAN STATE MOUNTAINEERS | W 69-47 | 3-1 | D. Donovan 19 | I. Haskins 8 | D. Donovan 11 |
| November 30, 2027 | HARVARD CRIMSON | W 72-65 | 4-1 | D. Lampley 22 | I. Haskins 6 | D. Donovan 12 |
| December 7, 2027 | SACRAMENTO STATE HORNETS | W 88-63 | 5-1 | I. Haskins 23 | N. Charles 7 | K. Walker 11 |
| December 9, 2027 | ILLINOIS-CHICAGO FLAMES Jimmy V Classic | W 73-62 | 6-1 | I. Haskins 20 | I. Haskins 6 | K. Walker 7 |
| December 10, 2027 | MIDDLE TENNESSEE BLUE RAIDERS Jimmy V Classic | W 68-52 | 7-1 | D. Donovan 16 | D. Donovan 3 | R. Fry 11 |
| December 11, 2027 | UTAH UTES Jimmy V Classic | W 78-65 | 8-1 | D. Donovan 21 | I. Haskins 5 | R. Fry 10 |
| December 14, 2027 | FLORIDA INTERNATIONAL PANTHERS | W 74-58 | 9-1 | D. Lampley 16 | D. Donovan 5 | R. Fry 7 |
| December 21, 2027 | @ Minnesota Golden Gophers | L 61-80 | 9-2 | D. Lampley 19 | I. Haskins 6 | D. Donovan 7 |
| December 26, 2027 | @ #14 Virginia Cavaliers* | L 75-94 | 9-3 | I. Haskins 17 | I. Haskins 4 | R. Fry 10 |
| December 28, 2027 | @ Miami (FL) Hurricanes* | L 59-64 | 9-4 | D. Lampley 14 | I. Haskins 4 | K. Walker 7 |
| January 2, 2028 | BOSTON COLLEGE EAGLES* | W 91-66 | 10-4 | D. Donovan 24 | I. Haskins 7 | D. Lampley 8 |
| January 4, 2028 | @ California Golden Bears* | L 51-68 | 10-5 | R. Fry 13 | I. Haskins 2 | D. Donovan 9 |
| January 9, 2028 | @ Florida State Seminoles* | L 74-80 OT | 10-6 | I. Haskins 20 | D. Lampley 5 | K. Walker 10 |
| January 11, 2028 | #1 DUKE BLUE DEVILS* | W 78-65 | 11-6 | D. Donovan 18 | I. Haskins 5 | D. Donovan 10 |
| January 16, 2028 | @ Notre Dame Fighting Irish* | L 59-65 | 11-7 | N. Charles 12 | D. Lampley 8 | K. Walker 9 |
| January 18, 2028 | @ North Carolina Tar Heels* | L 74-92 | 11-8 | D. Donovan 32 | I. Haskins 4 | K. Walker 5 |
| January 23, 2028 | @ Southern Methodist Mustangs* | L 82-92 | 11-9 | D. Donovan 29 | I. Haskins 8 | R. Fry 5 |
| January 25, 2028 | @ Pittsburgh Panthers* | W 90-88 | 12-9 | D. Donovan 26 | I. Haskins 5 | R. Fry 12 |
| January 30, 2028 | STANFORD CARDINAL* | W 75-58 | 13-9 | D. Lampley 25 | D. Lampley 6 | R. Fry 7 |
| February 1, 2028 | NC-STATE WOLFPACK* | W 70-55 | 14-9 | D. Lampley 23 | I. Haskins 5 | K. Walker 8 |
| February 6, 2028 | GEORGIA TECH YELLOW JACKETS* | W 82-62 | 15-9 | D. Donovan 22 | I. Haskins 13 | K. Walker 8 |
| February 8, 2028 | @ Virginia Tech Hokies* | W 69-62 | 16-9 | D. Lampley 18 | I. Haskins 11 | D. Lampley 6 |
| February 13, 2028 | WAKE FOREST DEMON DEACONS* | L 74-75 | 16-10 | D. Lampley 26 | I. Haskins 5 | R. Fry 9 |
| February 15, 2028 | #10 LOUISVILLE CARDINALS* | L 59-87 | 16-11 | R. Fry 17 | I. Haskins 3 | D. Lampley 5 |
| February 20, 2028 | @ #18 Syracuse Orange* | L 59-80 | 16-12 | K. Walker 10 | I. Haskins 4 | R. Fry 13 |
| February 22, 2028 | #11 VIRGINIA CAVALIERS* | W 83-70 | 17-12 | D. Donovan 31 | I. Haskins 6 | D. Donovan 10 |
| February 27, 2028 | PITTSBURGH PANTHERS* | W 90-80 | 18-12 | D. Donovan 21 | I. Haskins 6 | D. Donovan 11 |
| March 1, 2028 | #23 NORTH CAROLINA TAR HEELS* | W 71-66 | 19-12 | J. Blackshear 16 | I. Haskins 6 | R. Fry 12 |
| March 9, 2028 | @ Notre Dame Fighting Irish (17-14, 10-5 Home) ACC Tournament | - | | | | |
