| November 16, 2025 | PURDUE-FORT WAYNE MASTODONS | W 80-72 | 1-0 | D. Meeks 22 | A. Bayless 7 | I. Cunningham 12 |
| November 19, 2025 | @ Southern California Trojans | L 69-81 | 1-1 | I. Cunningham 15 | A. Bayless 5 | K. Johnson 9 |
| November 21, 2025 | VERMONT CATAMOUNTS Hall of Fame Classic | W 72-69 | 2-1 | K. Bennem 25 | A. Bayless 6 | D. Meeks 11 |
| November 22, 2025 | @ #7 Florida Gators Hall of Fame Classic | L 71-84 | 2-2 | I. Cunningham 21 | A. Bayless 3 | I. Cunningham 8 |
| November 24, 2025 | KENNESAW STATE OWLS | W 84-69 | 3-2 | K. Bennem 18 | D. Meeks 6 | I. Cunningham 10 |
| November 30, 2025 | OHIO BOBCATS | W 76-75 OT | 4-2 | K. Johnson 26 | A. Bayless 7 | D. Meeks 14 |
| December 2, 2025 | DAYTON FLYERS | W 84-55 | 5-2 | I. Cunningham 21 | A. Bayless 6 | I. Cunningham 7 |
| December 7, 2025 | SOUTHERN MISSISSIPPI GOLDEN EAGLES | W 80-76 | 6-2 | K. Johnson 19 | K. Bennem 4 | I. Cunningham 11 |
| December 13, 2025 | MD-BALTIMORE COUNTY RETRIEVERS | W 100-78 | 7-2 | A. Bayless 22 | A. Bayless 5 | I. Cunningham 10 |
| December 21, 2025 | NOTRE DAME FIGHTING IRISH | W 74-65 | 8-2 | I. Cunningham 20 | A. Bayless 5 | D. Meeks 10 |
| December 26, 2025 | #3 CONNECTICUT HUSKIES* | W 96-81 | 9-2 | A. Bayless 24 | A. Bayless 8 | A. Bayless 9 |
| December 28, 2025 | @ Creighton Blue Jays* | L 80-86 | 9-3 | I. Cunningham 21 | A. Bayless 3 | I. Cunningham 11 |
| December 30, 2025 | @ DePaul Blue Demons* | L 66-85 | 9-4 | I. Cunningham 17 | A. Bayless 5 | I. Cunningham 11 |
| January 2, 2026 | MARQUETTE GOLDEN EAGLES* | W 85-77 | 10-4 | I. Cunningham 24 | K. Bennem 6 | I. Cunningham 9 |
| January 4, 2026 | @ #21 Providence Friars* | L 75-87 | 10-5 | K. Johnson 17 | A. Bayless 6 | A. Bayless 6 |
| January 6, 2026 | XAVIER MUSKETEERS* | L 66-77 | 10-6 | A. Bayless 12 | A. Bayless 6 | D. Meeks 11 |
| January 13, 2026 | GEORGETOWN HOYAS* | W 84-67 | 11-6 | K. Bennem 20 | A. Bayless 8 | J. Beeson 10 |
| January 18, 2026 | @ Villanova Wildcats* | L 77-88 | 11-7 | K. Bennem 23 | A. Bayless 7 | A. Bayless 7 |
| January 20, 2026 | @ Seton Hall Pirates* | W 86-81 | 12-7 | A. Bayless 19 | K. Bennem 5 | I. Cunningham 8 |
| January 27, 2026 | ST. JOHNS RED STORM* | W 87-68 | 13-7 | K. Johnson 19 | A. Bayless 5 | K. Johnson 9 |
| February 1, 2026 | #18 PROVIDENCE FRIARS* | W 81-59 | 14-7 | D. Meeks 19 | A. Bayless 5 | I. Cunningham 8 |
| February 3, 2026 | @ Georgetown Hoyas* | W 76-66 | 15-7 | A. Bayless 19 | A. Bayless 3 | D. Meeks 11 |
| February 8, 2026 | SETON HALL PIRATES* | W 86-76 | 16-7 | I. Cunningham 20 | K. Bennem 4 | I. Cunningham 10 |
| February 10, 2026 | #25 VILLANOVA WILDCATS* | L 68-76 | 16-8 | K. Bennem 16 | A. Bayless 5 | D. Meeks 10 |
| February 15, 2026 | @ Xavier Musketeers* | W 85-81 | 17-8 | K. Bennem 17 | A. Bayless 6 | D. Meeks 9 |
| February 17, 2026 | @ St. Johns Red Storm* | W 79-67 | 18-8 | A. Bayless 16 | A. Bayless 5 | K. Johnson 5 |
| February 22, 2026 | @ Marquette Golden Eagles* | L 70-89 | 18-9 | K. Bennem 19 | A. Bayless 3 | K. Johnson 8 |
| February 24, 2026 | @ #3 Connecticut Huskies* | L 58-70 | 18-10 | K. Bennem 20 | A. Bayless 4 | I. Cunningham 11 |
| March 1, 2026 | DEPAUL BLUE DEMONS* | W 88-76 | 19-10 | K. Bennem 18 | A. Bayless 5 | D. Meeks 7 |
| March 3, 2026 | CREIGHTON BLUE JAYS* | W 88-83 | 20-10 | I. Cunningham 23 | K. Bennem 7 | I. Cunningham 14 |
| March 10, 2026 | @ #21 Villanova Wildcats Big East Tournament | L 76-86 | 20-11 | K. Johnson 16 | A. Bayless 6 | I. Cunningham 11 |
| March 16, 2026 | SAINT LOUIS BILLIKENS NCAA Tournament | W 81-77 | 21-11 | K. Johnson 16 | A. Bayless 7 | I. Cunningham 12 |
| March 18, 2026 | @ Florida Gators (27-8, 14-2 Home) NCAA Tournament | - | | | | |
