| November 15, 2027 | MCNEESE STATE COWBOYS | L 67-80 | 0-1 | B. McClintock 18 | B. Lam 6 | W. McCoy 10 |
| November 18, 2027 | @ Louisiana State Fighting Tigers | L 64-87 | 0-2 | J. Lawson 18 | J. Lawson 6 | W. McCoy 7 |
| November 22, 2027 | INCARNATE WORD CARDINALS | W 86-80 OT | 1-2 | B. Lam 19 | J. Lawson 9 | A. Ford 9 |
| November 25, 2027 | @ Northwestern Wildcats ESPN Events Invitational | W 71-57 | 2-2 | M. Rhodes 18 | J. Lawson 8 | M. Rhodes 9 |
| November 26, 2027 | @ #9 West Virginia Mountaineers ESPN Events Invitational | L 57-75 | 2-3 | B. Lam 17 | J. Lawson 8 | W. McCoy 8 |
| November 29, 2027 | WESTERN MICHIGAN BRONCOS | W 81-65 | 3-3 | W. McCoy 17 | J. Lawson 6 | T. Calhoun 7 |
| December 2, 2027 | @ Illinois State Redbirds | L 78-92 | 3-4 | B. Lam 22 | J. Lawson 5 | W. McCoy 8 |
| December 6, 2027 | CENTRAL MICHIGAN CHIPPEWAS | W 86-79 | 4-4 | B. Lam 23 | J. Lawson 10 | M. Rhodes 8 |
| December 13, 2027 | CORNELL BIG RED | W 73-59 | 5-4 | J. Lawson 20 | J. Lawson 6 | W. McCoy 16 |
| December 20, 2027 | TEXAS A&M-COMM. LIONS | W 88-71 | 6-4 | B. Lam 26 | J. Lawson 9 | W. McCoy 10 |
| December 26, 2027 | @ Clemson Tigers* | L 61-73 | 6-5 | B. Lam 17 | J. Lawson 8 | M. Rhodes 9 |
| December 28, 2027 | @ #11 North Carolina Tar Heels* | L 60-70 | 6-6 | B. Lam 13 | J. Lawson 5 | W. McCoy 7 |
| January 2, 2028 | WAKE FOREST DEMON DEACONS* | L 78-90 | 6-7 | J. Lawson 18 | J. Lawson 3 | W. McCoy 9 |
| January 4, 2028 | @ #14 Pittsburgh Panthers* | L 72-82 | 6-8 | W. McCoy 21 | J. Lawson 7 | W. McCoy 12 |
| January 9, 2028 | #9 LOUISVILLE CARDINALS* | L 71-82 | 6-9 | B. Lam 21 | B. Lam 5 | A. Ford 10 |
| January 11, 2028 | @ Syracuse Orange* | W 65-58 | 7-9 | J. Lawson 14 | J. Lawson 3 | M. Rhodes 8 |
| January 16, 2028 | STANFORD CARDINAL* | W 73-62 | 8-9 | W. McCoy 18 | W. McCoy 6 | W. McCoy 16 |
| January 18, 2028 | @ Florida State Seminoles* | L 85-86 OT | 8-10 | J. Lawson 18 | J. Lawson 5 | W. McCoy 10 |
| January 23, 2028 | NOTRE DAME FIGHTING IRISH* | W 87-63 | 9-10 | B. Lam 29 | J. Lawson 5 | W. McCoy 11 |
| January 25, 2028 | #8 DUKE BLUE DEVILS* | L 68-78 | 9-11 | J. Lawson 19 | J. Lawson 3 | B. McClintock 7 |
| January 30, 2028 | @ California Golden Bears* | W 96-81 | 10-11 | M. Rhodes 23 | J. Lawson 4 | A. Ford 9 |
| February 1, 2028 | VIRGINIA TECH HOKIES* | W 70-65 | 11-11 | B. Lam 25 | J. Lawson 3 | M. Rhodes 12 |
| February 6, 2028 | MIAMI (FL) HURRICANES* | W 92-82 | 12-11 | B. Lam 22 | J. Lawson 9 | B. Lam 4 |
| February 8, 2028 | @ Southern Methodist Mustangs* | L 79-85 | 12-12 | B. Lam 19 | J. Lawson 5 | B. McClintock 6 |
| February 13, 2028 | #7 VIRGINIA CAVALIERS* | L 82-94 | 12-13 | B. Lam 33 | J. Lawson 9 | W. McCoy 7 |
| February 15, 2028 | @ NC-State Wolfpack* | L 65-80 | 12-14 | J. Lawson 17 | J. Lawson 3 | M. Rhodes 7 |
| February 20, 2028 | #16 GEORGIA TECH YELLOW JACKETS* | L 80-93 | 12-15 | D. Ross 18 | J. Lawson 4 | W. McCoy 7 |
| February 22, 2028 | SOUTHERN METHODIST MUSTANGS* | L 74-80 | 12-16 | B. Lam 24 | J. Lawson 7 | M. Rhodes 8 |
| February 27, 2028 | @ #10 Virginia Cavaliers* | L 73-79 | 12-17 | B. Lam 19 | M. Rhodes 4 | W. McCoy 8 |
| March 1, 2028 | @ Wake Forest Demon Deacons* | W 78-76 | 13-17 | B. Lam 25 | J. Lawson 8 | M. Rhodes 8 |
| March 8, 2028 | @ Florida State Seminoles ACC Tournament | L 72-76 OT | 13-18 | W. McCoy 17 | J. Lawson 8 | W. McCoy 13 |
