| November 16, 2027 | NEVADA WOLFPACK | W 89-72 | 1-0 | N. Bliss 18 | B. Augustine 4 | N. Stokes 7 |
| November 19, 2027 | @ Colorado Buffaloes | W 77-59 | 2-0 | N. Bliss 18 | L. Simpson 9 | N. Stokes 13 |
| November 23, 2027 | JAMES MADISON DUKES | W 83-75 | 3-0 | N. Bliss 12 | L. Simpson 6 | W. Ramsey 10 |
| November 26, 2027 | TEXAS STATE BOBCATS | W 85-71 | 4-0 | N. Stokes 16 | W. Goodwin 4 | N. Stokes 9 |
| November 30, 2027 | STONY BROOK SEAWOLVES | W 87-71 | 5-0 | N. Bliss 20 | L. Simpson 7 | W. Ramsey 13 |
| December 7, 2027 | KANSAS CITY KANGAROOS | W 98-70 | 6-0 | N. Bliss 19 | N. Bliss 5 | W. Ramsey 11 |
| December 13, 2027 | CORNELL BIG RED | L 84-88 | 6-1 | N. Bliss 24 | L. Simpson 6 | N. Bliss 7 |
| December 16, 2027 | UC-IRVINE ANTEATERS Las Vegas Showdown | L 76-99 | 6-2 | N. Bliss 13 | L. Simpson 5 | B. Augustine 7 |
| December 21, 2027 | FLORIDA INTERNATIONAL PANTHERS | W 96-71 | 7-2 | N. Bliss 17 | L. Simpson 8 | B. Augustine 9 |
| December 26, 2027 | @ #24 North Carolina Tar Heels* | L 56-77 | 7-3 | N. Bliss 17 | L. Simpson 5 | B. Augustine 10 |
| December 28, 2027 | NC-STATE WOLFPACK* | L 67-73 | 7-4 | N. Bliss 13 | N. Bliss 4 | L. Harrell 7 |
| January 2, 2028 | @ Clemson Tigers* | L 66-91 | 7-5 | L. Simpson 15 | L. Simpson 7 | W. Ramsey 5 |
| January 4, 2028 | SOUTHERN METHODIST MUSTANGS* | W 105-90 | 8-5 | N. Stokes 26 | L. Simpson 9 | B. Augustine 9 |
| January 9, 2028 | @ Virginia Tech Hokies* | W 96-67 | 9-5 | L. Simpson 16 | L. Simpson 7 | L. Simpson 8 |
| January 11, 2028 | @ Stanford Cardinal* | W 90-82 | 10-5 | L. Simpson 27 | L. Simpson 5 | B. Augustine 9 |
| January 16, 2028 | #9 VIRGINIA CAVALIERS* | L 89-101 | 10-6 | N. Bliss 31 | L. Simpson 8 | B. Augustine 9 |
| January 18, 2028 | @ #22 Syracuse Orange* | L 84-89 OT | 10-7 | N. Bliss 22 | L. Simpson 7 | B. Augustine 8 |
| January 23, 2028 | #1 DUKE BLUE DEVILS* | L 67-72 | 10-8 | N. Bliss 18 | L. Simpson 4 | B. Augustine 10 |
| January 25, 2028 | CALIFORNIA GOLDEN BEARS* | L 72-74 | 10-9 | N. Bliss 17 | L. Simpson 8 | B. Augustine 13 |
| January 30, 2028 | #11 LOUISVILLE CARDINALS* | L 64-80 | 10-10 | N. Bliss 13 | J. Cameron 3 | W. Ramsey 9 |
| February 1, 2028 | @ Wake Forest Demon Deacons* | L 72-93 | 10-11 | J. Cameron 13 | L. Simpson 7 | N. Bliss 5 |
| February 6, 2028 | @ Pittsburgh Panthers* | L 74-86 | 10-12 | B. Augustine 25 | L. Simpson 6 | L. Simpson 6 |
| February 8, 2028 | MIAMI (FL) HURRICANES* | W 80-72 | 11-12 | L. Simpson 19 | L. Simpson 4 | B. Augustine 10 |
| February 13, 2028 | FLORIDA STATE SEMINOLES* | W 101-90 | 12-12 | N. Bliss 43 | L. Simpson 9 | N. Stokes 6 |
| February 15, 2028 | @ Georgia Tech Yellow Jackets* | W 89-78 | 13-12 | B. Augustine 22 | N. Bliss 6 | L. Harrell 8 |
| February 20, 2028 | @ Notre Dame Fighting Irish* | W 73-69 | 14-12 | N. Bliss 21 | L. Simpson 12 | W. Ramsey 13 |
| February 22, 2028 | NOTRE DAME FIGHTING IRISH* | L 99-102 OT | 14-13 | B. Augustine 22 | L. Simpson 5 | B. Augustine 10 |
| February 27, 2028 | @ California Golden Bears* | L 47-93 | 14-14 | N. Bliss 11 | L. Simpson 4 | L. Harrell 8 |
| March 1, 2028 | WAKE FOREST DEMON DEACONS* | L 66-86 | 14-15 | L. Simpson 14 | L. Simpson 2 | W. Ramsey 7 |
| March 8, 2028 | @ Wake Forest Demon Deacons (15-16, 10-6 Home) ACC Tournament | - | | | | |
