| November 14, 2027 | @ #20 Alabama Crimson Tide | L 85-86 | 0-1 | M. Winder 17 | S. Ohnstad 4 | B. Chappel 8 |
| November 17, 2027 | MARSHALL THUNDERING HERD | W 85-47 | 1-1 | S. Ohnstad 35 | M. Winder 4 | B. Chappel 12 |
| November 21, 2027 | STANFORD CARDINAL WSSN Classic | L 71-83 | 1-2 | M. Winder 21 | S. Ohnstad 5 | M. Winder 8 |
| November 30, 2027 | @ Northwestern Wildcats | L 83-92 | 1-3 | S. Ohnstad 20 | M. Winder 6 | S. Ohnstad 5 |
| December 1, 2027 | MOREHEAD STATE EAGLES | W 94-59 | 2-3 | M. Winder 26 | S. Ohnstad 12 | S. Ohnstad 7 |
| December 5, 2027 | WESTERN MICHIGAN BRONCOS | W 73-47 | 3-3 | S. Ohnstad 20 | C. Carberry 6 | B. Chappel 12 |
| December 8, 2027 | @ Auburn Tigers | W 74-70 | 4-3 | S. Ohnstad 19 | M. Winder 4 | B. Chappel 7 |
| December 12, 2027 | HARVARD CRIMSON | W 68-48 | 5-3 | B. Chappel 22 | S. Ohnstad 5 | J. Lentz 14 |
| December 19, 2027 | @ Southern California Trojans | W 89-76 | 6-3 | J. Lentz 20 | J. Lentz 4 | B. Chappel 5 |
| December 28, 2027 | UTAH UTES* | L 63-77 | 6-4 | S. Ohnstad 19 | S. Ohnstad 3 | J. Lentz 9 |
| December 30, 2027 | @ #16 Houston Cougars* | W 78-77 | 7-4 | M. Winder 21 | S. Ohnstad 6 | J. Lentz 11 |
| January 4, 2028 | KANSAS STATE WILDCATS* | W 78-66 | 8-4 | S. Ohnstad 22 | S. Ohnstad 5 | B. Chappel 14 |
| January 6, 2028 | @ #4 Brigham Young Cougars* | L 69-85 | 8-5 | S. Ohnstad 16 | J. Lentz 3 | J. Lentz 11 |
| January 9, 2028 | @ #25 Arizona Wildcats* | L 49-70 | 8-6 | S. Ohnstad 17 | M. Winder 4 | J. Lentz 8 |
| January 16, 2028 | #4 KANSAS JAYHAWKS* | L 74-79 | 8-7 | M. Winder 18 | S. Ohnstad 9 | M. Winder 6 |
| January 18, 2028 | #11 IOWA STATE CYCLONES* | L 84-95 | 8-8 | S. Ohnstad 19 | C. Carberry 6 | B. Chappel 8 |
| January 20, 2028 | @ Utah Utes* | W 84-69 | 9-8 | J. Cuyler 18 | S. Ohnstad 4 | C. Carberry 8 |
| January 25, 2028 | @ West Virginia Mountaineers* | W 84-83 | 10-8 | S. Ohnstad 17 | M. Winder 4 | J. Lentz 7 |
| January 27, 2028 | CINCINNATI BEARCATS* | W 91-77 | 11-8 | M. Winder 19 | C. Carberry 3 | B. Chappel 7 |
| February 1, 2028 | @ Arizona State Sun Devils* | W 79-68 | 12-8 | S. Ohnstad 19 | S. Ohnstad 6 | J. Lentz 9 |
| February 3, 2028 | COLORADO BUFFALOES* | W 80-70 | 13-8 | J. Cuyler 24 | S. Ohnstad 5 | J. Lentz 9 |
| February 6, 2028 | @ Texas Christian Horned Frogs* | L 65-83 | 13-9 | S. Ohnstad 21 | J. Lentz 3 | C. Carberry 8 |
| February 10, 2028 | CENTRAL FLORIDA KNIGHTS* | W 84-59 | 14-9 | M. Winder 23 | S. Ohnstad 10 | B. Chappel 7 |
| February 13, 2028 | #16 ARIZONA WILDCATS* | W 90-87 | 15-9 | S. Ohnstad 25 | S. Ohnstad 6 | J. Lentz 10 |
| February 17, 2028 | @ Oklahoma State Cowboys* | W 91-78 | 16-9 | S. Ohnstad 27 | M. Winder 4 | B. Chappel 11 |
| February 22, 2028 | @ Kansas State Wildcats* | L 84-90 | 16-10 | S. Ohnstad 22 | M. Winder 7 | J. Lentz 7 |
| February 24, 2028 | TEXAS TECH RED RAIDERS* | W 85-76 | 17-10 | M. Winder 24 | M. Winder 9 | J. Lentz 8 |
| March 1, 2028 | @ #6 Kansas Jayhawks* | L 52-69 | 17-11 | S. Ohnstad 11 | M. Winder 3 | J. Lentz 6 |
| March 3, 2028 | TEXAS CHRISTIAN HORNED FROGS* | W 88-78 | 18-11 | S. Ohnstad 30 | S. Ohnstad 6 | C. Carberry 6 |
| March 9, 2028 | TBD Big 12 Tournament | - | | | | |
